Selected Publications

Hecker L. Mechanisms and Consequences of Oxidative Stress in Lung Disease: Therapeutic Implications for an Aging Populace. 2017. Am J Physiol Lung Cell Mol Physiol. In Press.PubMed ID: 29351446
https://www.ncbi.nlm.nih.gov/pubmed/29351446

Palumbo S, Shin Y, Ahmad K, Desai A, Quijada H, Mohamed M, Knox A, Colson B, Sammani S, Wang T, Garcia JGN, and Hecker L. 2017. Dysregulated Nox4 ubiquitination contributes to redox imbalance and age-related severity of acute lung injury. American Journal of Physiology – Lung Cellular and Molecular Physiology. 312(3):297-308. PubMed ID: 28062482
https://www.ncbi.nlm.nih.gov/pubmed/28062482

Bime C, Zhou T, Wang T, Slepian MJ, Garcia JG, Hecker L. 2016. Reactive oxygen species-associated molecular signature predicts survival in patients with sepsis. Pulmonary Circulation. 6(2)196-201. PubMed ID: 27252846
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4869924/

Hecker L, Thannickal VJ. 2016. Getting to the core of fibrosis: targeting redox imbalance in aging. Annals of Translational Medicine. 4(5):93. PubMed ID: 27047952
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4791330/

Hecker L, Logsdon NJ, Kurundkar D, Kurundkar A, Bernard K, Hock T, Meldrum E, Sanders YY, Thannickal VJ. 2014. Reversal of persistent fibrosis in aging by targeting Nox4-Nrf2 redox imbalance. Science Translational Medicine. 6(231):231-247. PubMed ID: 24718857
https://www.ncbi.nlm.nih.gov/pubmed/24718857

Sanders YY, Liu H, Zhang X, Bernard K, Hecker L, Desai L, Liu G, Thannickal VJ. 2013. Histone modifications in senescence-associated resistance to apoptosis by oxidative stress. Redox Biology. 1:8-16. PubMed ID: 24024133
https://www.ncbi.nlm.nih.gov/pubmed/24024133

Zhou Y, Huang X, Hecker L, Kurundkar D, Kurundkar A, Liu H, Jin T, Desai L, Bernard K, Thannickal VJ. 2013. Inhibition of mechanosensitive signaling in myofibroblasts ameliorates experimental pulmonary fibrosis. Journal of Clinical Investigation. 123(3): 1096-1108. PubMed ID: 23434591
https://www.ncbi.nlm.nih.gov/pubmed/23434591

Hecker L, Cheng J, Thannickal VJ. 2012. Targeting NOX enzymes in pulmonary fibrosis. Cellular and Molecular Life Sciences. 69(14): 2365-2371. PubMed ID: 22618245
https://www.ncbi.nlm.nih.gov/pubmed/22618245

Hecker L, Jagirdar R, Jin TJ, Thannickal VJ. 2011. Reversible differentiation of myofibroblasts by MyoD. Experimental Cell Research. 317(13):1914-1921. PubMed ID: 21440539
https://www.ncbi.nlm.nih.gov/pubmed/21440539

Hecker L, Thannickal VJ. 2011. Nonresolving fibrotic disorders: idiopathic pulmonary fibrosis as a paradigm of impaired tissue regeneration. American Journal of the Medical Sciences. 341(6):431-434. PubMed ID: 21613929
https://www.ncbi.nlm.nih.gov/pubmed/21613929

Hecker L, Vittal R, Jones T, Jagirdar R, Luckhardt TR, Horowitz JC, Pennathur S, Martinez FJ, Thannickal VJ. 2009. NADPH oxidase-4 mediates myofibroblast activation and fibrogenic responses to lung injury. Nature Medicine. 15(9):1077-1082. PubMed ID: 19701206
https://www.ncbi.nlm.nih.gov/pubmed/19701206